- Case Report
- Autosomal dominant hypocalcemia with Bartter syndrome due to a novel activating mutation of calcium sensing receptor, Y829C
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Keun Hee Choi, Choong Ho Shin, Sei Won Yang, Hae Il Cheong
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Clin Exp Pediatr. 2015;58(4):148-153. Published online April 22, 2015
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The calcium sensing receptor (CaSR) plays an important role in calcium homeostasis. Activating mutations of CaSR cause autosomal dominant hypocalcemia by affecting parathyroid hormone secretion in parathyroid gland and calcium resorption in kidney. They can also cause a type 5 Bartter syndrome by inhibiting the apical potassium channel in the thick ascending limb of the loop of Henle in the... |
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- Original Article
- Excess of leptin inhibits hypothalamic KiSS-1 expression in pubertal mice
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Sung Yeon Ahn, Sei Won Yang, Hee Jae Lee, Jong Seon Byun, Ji Yeon Om, Choong Ho Shin
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Clin Exp Pediatr. 2012;55(9):337-343. Published online September 14, 2012
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Purpose Leptin has been considered a link between metabolic state and reproductive activity. Defective reproductive function can occur in leptin-deficient and leptin-excessive conditions. The aim of this study was to examine the effects of centrally injected leptin on the hypothalamic KiSS-1 system in relation to gonadotropin-releasing hormone (GnRH) action in the initial stage of puberty. MethodsLeptin (1 µg) was injected directly into... |
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- Urinary 6-sulfatoxymelatonin level in girls and its relationship with obesity
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Jieun Lee, Juyoung Yoon, Jin A Lee, Seong Yong Lee, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2012;55(9):344-349. Published online September 14, 2012
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Purpose Short sleep duration is associated with obesity. Urinary 6-sulfatoxymelatonin (6-OHMS), the principal metabolite of melatonin, is closely related with sleep. We evaluated the difference in urinary 6-OHMS levels between obese girls and normal weight girls, and the relationship of urinary 6-OHMS with other hormones regulating body weight and metabolism. MethodsA total of 79 girls (6.3 to 12.4 years) were included in... |
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- Prevalence and risk factors of the metabolic syndrome in young adults with childhood-onset hypopituitary growth hormone deficiency
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Han Hyuk Lim, Min Jae Kang, In Suk Yun, Young Ah Lee, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2010;53(10):892-897. Published online October 31, 2010
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Purpose This study evaluated the prevalence of the metabolic syndrome (MetS) and risk factors for metabolic derangement in young adults with childhood-onset hypopituitary growth hormone deficiency (ACOHGHD). MethodsThirty patients with ACOHGHD who were treated with hormone-replacement therapy, aged 18 to 29 years, who visited the Seoul National University Children's Hospital between September 2009 and February 2010 were enrolled. Height, weight, waist circumference,... |
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- Remission rate and remission predictors of Graves disease in children and adolescents
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Sun Hee Lee, Seong Yong Lee, Hye Rim Chung, Jae Hyun Kim, Ji Hyun Kim, Young Ah Lee, Sei Won Yang, Choong Ho Shin
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Clin Exp Pediatr. 2009;52(9):1021-1028. Published online September 15, 2009
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Purpose : Medical therapy is the initial treatment for children with Graves disease to avoid complications of other treatments. However, optimal treatment for childhood Graves disease is controversial because most patients require relatively long periods of medical therapy and relapse is common after medication discontinuation. Therefore, this study aimed to search clinical or biochemical characteristics that could be used as... |
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- Growth responses to growth hormone therapy in children with attenuated growth
who showed normal growth hormone response to stimulation tests
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Jae Hyun Kim, Hey Rim Chung, Young Ah Lee, Sun Hee Lee, Ji Hyub Kim, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2009;52(8):922-929. Published online August 15, 2009
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Purpose:The aim was to investigate the clinical characteristics and responses to growth hormone (GH) therapy in children
with attenuated growth who showed normal GH responses to GH stimulation tests (GHST).
Methods:The study included 39 patients with height velocity (HV) of less than 4 cm/yr and normal GHST results. Clinical
characteristics of patients were analyzed retrospectively.
Results:Eleven were born as small for gestational age (SGA)... |
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- Development of metabolic syndrome and its correlation with insulin resistance in adult patients with Turner syndrome
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Joo Hwa Kim, Min Jae Kang, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2009;52(3):370-375. Published online March 15, 2009
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Purpose : The risk of metabolic syndrome (MS) and cardiovascular disease in Turner syndrome (TS) patients is high. We analyzed metabolic factors in adults with TS and evaluated the metabolic risk of insulin resistance.
Methods : Forty-three adults with TS were enrolled. The frequency of MS and the values of the metabolic factors were analyzed. Patients were divided into insulin... |
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- Factors for persistent growth hormone deficiency in young adults with childhood onset growth hormone deficiency
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Young Ah Lee, Hye Rim Chung, Se Min Lee, Jae Hyun Kim, Ji Hyun Kim, Sun Hee Lee, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2009;52(2):227-233. Published online February 15, 2009
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Purpose : Growth hormone (GH) replacement after retesting is necessary because impairment of body composition and cardiovascular health has been more severe in adult patients with persistent GH deficiency (GHD) from childhood to adulthood. This study aimed to investigate the factors for persistent GHD and define a highly probable group of persistent GHD in young adults with childhood-onset GHD.
Methods :... |
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- Case Report
- A case of testicular adrenal rest tumor in a
male child with congenital adrenal hyperplasia
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Joo Hwa Kim, Kyong Ah Yun, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2008;51(9):1018-1022. Published online September 15, 2008
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Testicular adrenal rest tumors are a well-known complication in male patients with congenital adrenal hyperplasia. Corticosteroid suppressive therapy usually results in the regression of these tumors. We describe a patient with 21-hydroxylase deficiency who developed bilateral testicular masses. Despite steroid suppressive therapy, the tumors did not regress and hormonal control was poor. Consequently, bilateral partial orchiectomies were performed. |
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- Review Article
- Epidemiologic characteristics of type 1 diabetes in children aged 14 years or
under in Korea, 1985-2000
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Choong Ho Shin
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Clin Exp Pediatr. 2008;51(6):569-575. Published online June 15, 2008
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Type 1 diabetes mellitus (T1DM) develops in genetically susceptible individuals as a result of progressive autoimmune destruction of beta cells. There is a large global variation in incidence among children aged 0-14 years. The incidence of T1DM in Korea is very low. The latest survey in Korea was conducted in 2001 by the Korean Society of Pediatrics to analyze ... |
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- Original Article
- Interpretation of screening for congenital adrenal hyperplasia in preterm infants
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Hye Rim Chung, Choong Ho Shin, Sei Won Yang, Kyong Ah Yun, Young Ah Lee, So Eun Park, Chang Won Choi, Byung Il Kim, Jung Hwan Choi, Junghan Song
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Clin Exp Pediatr. 2008;51(6):616-621. Published online June 15, 2008
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Purpose : This study was undertaken to identify factors that influence 17-OHP levels in preterm infants and to suggest a reasonable follow-up schedule of screening for congenital adrenal hyperplasia (CAH) in preterm infants.
Methods : The 17-OHP concentrations in filter paper blood spots of 427 preterm infants were obtained. The effects of gestational age (GA), systemic diseases, and antenatal dexamethasone... |
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- Case Report
- A case of simultaneously identified glycogen storage disease and
mucopolysaccharidosis
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Ju Young Lee, Jeong Ok Shim, Hye Ran Yang, Ju Young Chang, Choong Ho Shin, Jae Sung Ko, Jeong Kee Seo, Woo Sun Kim, Gyeong Hoon Kang, Jeong Han Song, Jong Won Kim
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Clin Exp Pediatr. 2008;51(6):650-654. Published online June 15, 2008
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Glycogen storage disease (GSD) and mucopolysaccharidosis (MPS) are both independently inherited disorders. GSD is a member of a group of genetic disorders involving enzymes responsible for the synthesis and degradation of glycogen. GSD leads to abnormal tissue concentrations of glycogen, primarily in the liver, muscle, or both. MPS is a member of a group of inherited lysosomal storage diseases, which... |
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- Pheochromocytoma associated with
cyanotic congenital heart disease
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Seung Joon Chung, Young Ah Lee, Choong Ho Shin, Sei Won Yang, Eun Jung Bae, Jung Il Noh
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Clin Exp Pediatr. 2008;51(1):93-97. Published online January 15, 2008
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Pheochromocytoma is a rare tumor of childhood, arising from adrenal medullary and chromaffin tissue. Because chronic hypoxia may induce pheochromocytoma, there have been several reports of pheochromocytoma development in cyanotic patients after corrective or palliative cardiac surgery. The variable clinical presentation of pheochromocytoma is obscured by both underlying heart disease and medications. If sudden hypertension, aggravation of a heart condition,... |
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- Original Article
- A study and the growth and the development of microvascular complications in patients with type 1 diabetes mellitus
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Young Ah Lee, Kyong-Ah Yun, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2007;50(2):190-197. Published online February 15, 2007
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Purpose : Reduced growth and microvascular complications have been recognized as consequences of type 1 diabetes mellitus (T1DM). We assessed the effect of T1DM on growth and factors associated with the development of microvascular complications.
Methods : We conducted a retrospective longitudinal evaluation of 154 patients above 16 years of age. We analyzed factors which affect final height standard deviation scores... |
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- Clinical, endocrinological and radiological courses in patients who
was initially diagnosed as idiopathic central diabetes insipidus
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Seung Joon Chung, Seong Yong Lee, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2007;50(11):1110-1115. Published online November 15, 2007
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Purpose : Idiopathic central diabetes insipidus (CDI) is defined in CDI patients without definite etiology. Some patients initially diagnosed as idiopathic CDI progressed to organic causes. We reviewed clinical, endocrinological, and radiological courses of 20 patients who was initially diagnosed as idiopathic CDI, to assess the predicting factors for progression to brain tumors.
Methods : We reviewed the medical data and... |
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- Factors affecting the final adult height in survivors of childhood brain tumors
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Kyong-Ah Yun, Young Ah Lee, Choong Ho Shin, Sei Won Yang, Hee Young Shin, Hyo Seop Ahn, Il Han Kim
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Clin Exp Pediatr. 2007;50(1):65-73. Published online January 15, 2007
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Purpose : Short stature is an important complication that impairs the quality of life in survivors of childhood brain tumors. We studied their final adult height (FAH) to evaluate risk factors for short stature.
Methods : We reviewed the medical data of 95 survivors of childhood brain tumors (64 males and 31 females) who had been followed up from 1982 to... |
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- Review Article
- Current use of growth hormone in children
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Choong Ho Shin
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Clin Exp Pediatr. 2006;49(7):703-709. Published online July 15, 2006
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Since the advent of growth hormone(GH), children with a wide variety of growth disorders have received GH treatment. In GH deficiency(GHD), Turner syndrome, chronic renal failure, children born small for gestational age, Prader-Willi syndrome, and idiopathic short stature, the therapeutic effects and safety profile of GH are reviewed. GH therapy has been clearly shown to improve height velocity and final... |
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- Case Report
- A case of Rothmund-Thomson syndrome
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Seung Hyo Kim, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2006;49(5):565-569. Published online May 15, 2006
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Rothmund-Thomson syndrome (RTS), is a rare autosomal recessive disorder, characterized by : skin photosensitivity, poikiloderma, sparse hair, sparse eyebrows/lashes, short stature, skeletal abnormalities, cataracts, and an increased risk of malignancy. Skeletal abnormalities include : dysplasia, absent or malformed bones, such as absent radii, osteopenia, and delayed bone formation. RTS is thought to result from chromosomal instability, and children with RTS... |
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- Original Article
- Endocrine dysfunction and growth in children with medulloblastoma
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In Suk Yoon, Ji Young Seo, Choong Ho Shin, Il Han Kim, Hee Young Shin, Sei Won Yang, Hyo Seop Ahn
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Clin Exp Pediatr. 2006;49(3):292-297. Published online March 15, 2006
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Purpose : In medulloblastoma, craniospinal radiation therapy combined with chemotherapy improves the prognosis of tumors but results in significant endocrine morbidities. We studied the endocrine morbidity, especially growth pattern changes.
Methods : The medical records of 37 patients with medulloblastoma were reviewed retrospectively for evaluation of endocrine function and growth. We performed the growth hormone stimulation test in 16 patients whose... |
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- Clinical Characteristics of Autoimmune Thyroid Disease Developed in Patients with Type 1 Diabetes Mellitus
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Se Min Lee, Hye Rim Chung, Su Young Hong, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2005;48(3):292-297. Published online March 15, 2005
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Purpose : It is known that 3-50 percent of type 1 diabetes mellitus(T1DM) patients develop autoimmune thyroid disease. We analyzed the clinical characteristics of autoimmune thyroid disease(AITD) developed in patients with T1DM in Korean.
Methods : The medical records of 139 patients, who were followed up in Department of Pediatrics, Seoul National University Children's Hospital from Jan. 1981 to Jul. 2004,... |
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- Case Report
- Hyperthyroidism Caused by a Mutation in the Thyrotropin Receptor Gene in Two Brothers
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Jae Hyun Kim, Sung Soo Lee, Jung Sub Lim, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2005;48(3):337-341. Published online March 15, 2005
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Thyrotropin receptor(TSHR) mutations must be considered when congenital hyperthyroidism has persisted, but there has been no evidence for autoimmunity. TSHR mutations leading to constitutive activation of the thyroid gland were identified as the molecular cause of autosomal dominant nonautoimmune hyperthyroidism and sporadic congenital hyperthyroidism. We report two cases of hyperthyroidism caused by germline TSHR mutation who presented with exessive sweating... |
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- Original Article
- Factors Affecting Final Adult Height in Patients with Turner Syndrome
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Jae Hyun Kim, Sung Soo Lee, Su Young Hong, Hye Rim Chung, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2005;48(2):191-196. Published online February 15, 2005
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Purpose : Short stature is one of the characteristic features of Turner syndrome. We investigated the factors affecting final adult height(FAH) in patients with Turner syndrome.
Methods : The study group was comprised of 60 patients who were diagnosed with Turner syndrome by chromosomal study and clinical phenotypes and attained FAH. Data were obtained from retrospective review of the medical records.... |
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- Factors Affecting the Increments of Body Mass Index in Adult Survivors of Childhood Brain Tumors
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Jae Ho Yoo, Sung Yeon Ahn, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2004;47(9):970-977. Published online September 15, 2004
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Purpose : The purpose of this study was to evaluate the factors affecting the increments of body mass index(BMI) in adult survivors from childhood brain tumors.
Methods : We retrospectively reviewed medical records of 63 patients who were diagnosed with brain tumors and treated at Seoul National University Children's Hospital between 1982 and 2000. We evaluated the factors affecting adult BMI(aBMI)... |
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- Alteration of Bone Metabolism Markers According to the Progression of Puberty
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Seong Yong Lee, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2004;47(2):140-149. Published online February 15, 2004
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Purpose : The object of this study is to evaluate bone metabolism in healthy adolescents according to the progression of puberty.
Methods : Forty boys(13.9?.7 years) and 42 girls(12.1?.6 years) were classified by Tanner stage (TS) and bone age. Serum levels of osteocalcin(OC) and bone specific alkaline phosphatase(BALP) were measured as bone formation markers. Serum level of C-terminal telopeptide of type... |
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- Clinical Characteristic of Chronic Autoimmune Thyroiditis in Children
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Hye Rim Chung, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2004;47(1):76-80. Published online January 15, 2004
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Purpose : Although chronic autoimmune thyroiditis(AIT) is known to progress into overt hypothyroidism in adults, the outcomes of this disorder in pediatric patients are different from those in adults, so it is hard to predict its course. We reviewed clinical characteristics of chronic AIT in children.
Methods : The medical records of 94 children, who were diagnosed as AIT, were analyzed,... |
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- The Separate and Combined Effects of Insulin, Dexamethasone and
Growth Hormone on the OB Gene Expression and Leptin Secretion
from Cultured Human Visceral Adipose Tissue
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Il Tae Hwang, Kyung Hee Kim, Jin Soon Hwang, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2003;46(8):795-802. Published online August 15, 2003
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Purpose : We investigated the hormonal control of OB gene expression and leptin secretion in cultured human visceral adipose tissue.
Methods : Visceral adipose tissues were cultured for up to 48 hrs in modified Eagle's medium with varying concentration of hormones : Control(no hormone), bovine insulin(100 nM), Dexamethasone(DEX, 100 nM), growth hormone(GH, 40 ng/mL), insulin+DEX(100 nM each), insulin+DEX+GH(100 nM insulin... |
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- Endocrine Function and Growth in Children with Craniopharyngioma
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Yoo Mi Chung, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2003;46(3):277-283. Published online March 15, 2003
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Purpose : Craniopharyngiomas are often accompanied by severe endocrine disorders. Although there is universal growth hormone deficiency(GHD), the resulting growth pattern is very heterogeneous. We report the growth and endocrine outcome of 44 children with craniopharyngioma, with emphasis on initial symptoms, growth before and during growth hormone(GH) treatment and spontaneous growth in spite of GHD.
Methods : We performed a... |
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- Changes of Bone Metabolism Markers and Bone Mineral
Density with Improvement of Thyroid Function in
Children and Adolescents with Hyperthyroidism
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Min Ho Jung, Choong Ho Shin, Sei Won Yang, Byung Churl Lee
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Clin Exp Pediatr. 2002;45(6):743-753. Published online June 15, 2002
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Purpose : Dynamics of bone mineral density(BMD) and bone metabolism in children and adolescents with hyperthyroidism have not been thoroughly investigated. The aim of this study was to study how the improvement of thyroid function with antithyroid treatment influenced bone metabolism and BMD in children and adolescents with hyperthyroidism.
Methods : Serum levels of osteocalcin(OC), bone-specific alkaline phosphatase(b-ALP), and carboxyterminal telopeptide... |
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- Clinical Characteristics of Type 2 Diabetes in
Children and Adolescents
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Seong Yong Lee, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2002;45(6):754-763. Published online June 15, 2002
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Purpose : The incidence of type 2 diabetes in children and adolescents has been reported to increase recently. The aim of this study is to investigate the clinical features of type 2 diabetes developing during childhood and adolescent period.
Methods : The medical records of 33 patients with type 2 diabetes were reviewed. We analysed clinical manifestations, demographic data, and modes... |
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- Effects of Insulin Level on Dyslipidemia in
Children with Simple Obesity
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Jung Sub Lim, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2002;45(6):764-772. Published online June 15, 2002
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Purpose : Obesity is closely related to insulin resistance, compensatory hyperinsulinemia and dyslipidemia in adults. We identified the effect of obesity measured by BMI and insulin resistance on dyslipidemia in children and adolescents.
Methods : The fasting serum insulin, glucose, total cholesterol, triglyceride, HDL- and LDL-cholesterol were measured and insulin resistance(HOMA-IR) was calculated in 35 children with simple obesity(age :... |
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- Clinical Lecture
- Type 1 Diabetes Mellitus
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Choong Ho Shin
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Clin Exp Pediatr. 2002;45(10):1181-1191. Published online October 15, 2002
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- Factors Related to the Development of Microalbuminuria in
Children and Adolescents with Type 1 Diabetes Mellitus
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Min Ho Jung, Pei Tai Wan, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2001;44(5):577-586. Published online May 15, 2001
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Purpose : We observed the prevalence rate of microalbuminuria(MA) and its relationship with the various clinical factors in children and adolescents with type 1 diabetes mellitus(DM).
Methods : Seventy two children and adolescents(26 males and 46 females, 17.1±3.0 years) were included. MA was defined as 24 hour urine microalbumin >30mg/day(20μg/min). Subjects were classified into three groups(normoalbuminuria, transient MA, or persistent MA).... |
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- Clinical Characteristics of Williams Syndrome
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Choong Ho Shin, Ho Sung Kim, Sei Won Yang, Jung Yun Choi
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Clin Exp Pediatr. 2001;44(4):443-449. Published online April 15, 2001
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Purpose : Williams syndrome(WS) is an autosomal dominant disorder resulting from a submicroscopic deletion of contiguous genes on the long arm of chromosome 7. We evaluated the physical, neurodevelopmental, and behavioral characteristics of children and adults with WS confirmed by fluorescence in situ hybridization.
Methods : The clinically suspicious twelve cases with cardiac anomaly were confirmed as WS with fluorescence in... |
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- Congenital Chloride Diarrhea in 5 Korean Infants
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Dong Hun Rhie, Sun Hwan Bae, Ji Eun Choi, Bo Young Yun, Dong Woo Son, Choong Ho Shin, Kyung Hee Park, Jae Sung Ko, Jeong Kee Seo
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Clin Exp Pediatr. 2000;43(11):1465-1472. Published online November 15, 2000
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Purpose : Congenital chloride diarrhea(CLD) is an autosomal recessive disease characterized by life-long watery diarrhea of prenatal onset with high fecal Cl- concentration. Recent studies have revealed that the protein product of the down-regulated in adenoma(DRA) gene is an intestinal anion transporter molecule and causes CLD when mutated. We investigated the clinical characteristics of CLD in Korean infants in order... |
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- Re-Evaluation of Neonatal Screening Tests for Inborn Errors of
Metabolism with Dried Filter Paper Blood Spots
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Kye Shik Shim, Jin Soon Hwang, Jung Sub Lim, Se Young Kim, Choong Ho Shin, Sei Won Yang, Jung Hwan Choi, Chong Ku Yun, Jung-Han Song
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Clin Exp Pediatr. 1999;42(12):1639-1644. Published online December 15, 1999
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Purpose : There have been high rates of false positive and recall in neonatal screening test using the cut-off points set by the manufacturing company. So, it is necessary to re-evaluate the cut off values to minimize the false positive rates.
Methods : We collected capillary blood in dry filter paper from 996 healthy neonates on the third day in cases... |
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- Case Report
- A Case of Type Ⅰ Glanzmann's Thrombasthenia Diagnosed by Flow Cytometry
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Mun Su Lee, Choong Ho Shin, Kyu Young Kim, Dong Woo Son, Hwa Ryung Chung, Do Hyun Kim
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Clin Exp Pediatr. 1999;42(1):133-137. Published online January 15, 1999
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Glanzmann's thrombasthenia is a rare autosomal recessive hemorrhagic disorder of platelet function with missing or abnormal platelet plasma membrane glycoprotein Ⅱb-Ⅲa, which functions as a receptor for fibrinogen. We have experienced a case of thrombasthenia in a 6-year-old female whose chief complaints were easy bruising, frequent epistaxis, arthralgia and swelling of the right ankle joint. Bleeding time was prolonged in... |
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- Case Report
- A Case of Mauriac's syndrome
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Se Young Kim, Choong Ho Shin, Il Soo Ha, Hae Il Cheong, Sei Won Yang, Yong Choi, Hyung Ro Moon
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Clin Exp Pediatr. 1996;39(7):1020-1024. Published online July 15, 1996
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Mauriac's syndrome was described in the 1920s, as a triad of poorly controlled insulin
dependent diabetes mellitus, profound growth retardation, and hepatomgaly. Following the wide
availability of insulin and intensification of diabetic control, this entity has become quite rare. A
9-year-old female child was transferred to pediatric OPD of SNUCH because of hyperglycemia,
short stature, and visual disturbance. Five years prior to admission, she... |
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- Original Article
- Study on the Thyroid Function of Neonate Born to Mother with Hyperthyroidism
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Choong Ho Shin, Se Young Kim, Sei Won Yang, Jung Hwan Choi, Chong Ku Park
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Clin Exp Pediatr. 1996;39(1):106-114. Published online January 15, 1996
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Purpose : In newborns from mothers with Graves' disease, neonatal transient hyperthyroidism or hypothyroidism may develop early in life. We evaluated the incidence and prognosis of neonatal thyroid dysfunction in neonates born to mothers with hyperthyroidism during pregnancy.
Methods : We measured blood T4, T3, TSH levels and TSH-R-Ab titer in 48 hyperthyroid
mothers and their babies between 1988 and 1994.
Results :... |
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- Cushing Syndrome in Children and Adolescents
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Choong Ho Shin, Sei Won Yang, Hyung Ro Moon
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Clin Exp Pediatr. 1995;38(12):1677-1685. Published online December 15, 1995
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Purpose : Cushing syndrome occurs rarely in children and adolescents. The clinical manifestation is variable and growth is usually adversely affected.
Methods : We retrospectively analyzed 8 patients with Cushing syndrome between the ages of 1 and 14 year who were admitted to the pediatric department of Seoul National University Children's Hospital during the period from 1978 to 1995.
Results : 1)... |
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